Liquid production from shales do not follow conventional wisdom due to the highly complex nature of multiphase flow in hydraulically fractured reservoirs. Developing a comprehensive understanding of the kind of impact that various geological, fluid, rock-fluid, completion, and operational parameters have on multiphase flow is essential to shale production evaluation. In addition to developing a theoretical framework, analytical and simulation tools are applied to thousands of wells in prolific liquid plays in the USA. Conclusions from this comprehensive study will help us better understand oil shale behavior and optimize production strategies.